Nonstimulant Medications

Nonstimulant Medications

Generic Medication Brand Names Dosage Forms Starting Dose Max Dose Notes
Guanfacine (extended release) Intuniv 1 mg, 2 mg, 3 mg, 4 mg 1 mg daily 4 mg in children 6-12; 7 mg in children 13+ α-agonist (α2A-specific) Orthostasis, sedation Can be given morning or evening; can be used together with stimulant
Clonidine (extended release tablet) Kapvay 0.1 mg 0.1 mg daily to BID 0.2mg BID α-agonist (less specific for α2A) BID dosing if higher than 0.1 mg per day
Atomoxetine Strattera 10 mg, 18 mg, 25 mg, 40 mg, 60 mg, 80 mg, 100 mg 10 mg daily 100mg daily Capsule cannot be opened
Viloxazine (extended release) Qelbree 100 mg, 150 mg, 200 mg 25 mg daily 70 mg daily (85 mg daily for adults) Capsule can be opened and sprinkled

Guanfacine and clonidine are alpha agonists; atomoxetine and viloxazine are norepinephrine reuptake inhibitors.

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Nonstimulant Medications


See the Ohio Department of Medicaid Unified Preferred Drugs List for information about prescription coverage for children enrolled in Medicaid.

Medicaid Unified Preferred Drugs List


Common Side Effects for Alpha Agonists (guanfacine and clonidine)

Lightheadedness/dizziness, especially when sitting up or standing up; mild sedation; headache.


Serious Side Effects for Alpha Agonists (Rare)

Syncope (fainting); large decreases in heart rate or blood pressure.


Common Side Effects for norepinephrine reuptake inhibitors (atomoxetine and viloxazine)

Gastrointestinal side effects: upset stomach, diarrhea, nausea, vomiting, reduced appetite, mild increases in irritability.


Serious  Side Effects for norepinephrine reuptake inhibitors (Rare)

Large increases in irritability, suicidal ideation, liver problems.